p53 Total and p53 (Phospho-Ser392) Dual Staining Assay Kit - 96 Well

The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman`s p53 Total and p53 (Phospho-Ser392) Dual Staining Assay Kit provides a pair of highly specific antibodies against total and phospho-p53 (Phospho-Ser392) together with a pair of matched DyLightTM (product of Pierce Biotechnology, Inc.) conjugated secondary antibodies in a ready-to-use format. (-)-Nutlin-3, a potent inhibitor of Mdm2-p53 interaction which has been shown to cause the activation and translocation of p53 between the cytoplasm and nuclear compartments, is included as a positive control.Application/Cell-Based Assay, Chemical Class/Assay Kits, Chemical Class/Nuclear Receptors, Research Area/Cancer, Research Area/Cell BiologySynonyms :