QBT Fatty Acid Uptake Assay Kit (Explorer) - 1Kit

Fatty acids are utilized for diverse cellular processes including mitochondria oxidation, membrane synthesis and energy sStorage. Pathologically increased intracellular fatty acid concentrations can cause cellular apoptosis and have been linked to insulin desensitization, Type 2 diabetes, obesity and cardiovascular disease. All of these intracellular processes are dependent upon fatty acids traversing the plasma membrane to get into the cell. Therefore, understanding the Fatty Acid Transport Proteins (FATP) that regulate this process is of great importance in biomedical research and drug discovery.FATPs are part of an evolutionarily conserved family of proteins of which six FATP family members are expressed in the human genome. While all six human FATPs are similar in function, they differ dramatically in their expression in various tissue and organs. The differences in FATP expression pattern therefore make it possible to selectively target the uptake of fatty acids into specific organs by using compounds that can discriminate between the different FATP family members.